Effect of Japanese quail ovomucoid on decreasing adiposity in rats
2009
Takeda, S.(Mukogawa Women's Univ., Nishinomiya, Hyogo (Japan)) | Tanaka, M. | Tashiro, M.
We investigated the effect of the Japanese quail trypsin inhibitor ovomucoid (OM) on lipid metabolism. Wistar male rats were divided into 4 groups and each group was given one of the following diets for 4 weeks: OM-free control diet, and OM diets containing 0.2%, 0.4% and 0.8% OM. After the feeding trial, body fat protein content of each rat was determined by X-ray computed tomography (CT). The rats were then dissected for measurement of their liver and plasma lipids and enzyme activities in liver and pancreas. No significant differences were seen in liver fats, while plasma triglyceride levels showed an OM-dose-dependent decrease. Pancreas weight, and protein and enzyme activities were increased in the OM-diet groups, especially in the 0.8% OM-diet group, which showed a significant difference compared with the control group. In the OM-diet groups, a dose-dependent decrease was present in liver glucose-6-phosphate dehydrogenase, malic enzyme and fatty acid synthesis activities. Moreover, X-ray CT analysis showed decreased percentages of rat body fat in the OM-diet groups. These results suggest that OM feeding induced a trophic effect on the pancreas, most likely leading to an increase in energy expenditure followed by a decrease in adiposity.
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