Effects of Hydrophilic Additives on the Release Rate of Protein Drugs
2007
Kwon, Y.K. (Seoul National University, Seoul, Republic of Korea) | Kim, J.H. (Dongguk University, Seoul, Republic of Korea) | Yoo, Y.J. (Seoul National University, Seoul, Republic of Korea), E-mail: [email protected]
It has been reported that hydrophobic additives generally decrease the release rate of protein drugs from drug delivery systems (DDS) and hydrophilic additives increase the release rate. In many cases, however, the addition of hydrophilic molecule is necessary for improving the stability of protein drugs. In the present work, the effects of hydrophilic additives on the release profiles, and micelle formation of protein drug formulations were investigated to develop a novel method for protein drug delivery. For model protein drug, bovine serum albumin (BSA) was employed and several hydrophilic additives were used in the release experiments.
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