Synthesis of some new substituted quinazolin-4-3H-ones as potent anticonvulsant agents
2009
Garg, N. (LLRM Medical Coll., Uttarpardesh (India). Dept. of Pharmacology) | Chandra, T. (LLRM Medical Coll., Uttarpardesh (India). Dept. of Pharmacology) | Lata, S. (LLRM Medical Coll., Uttarpardesh (India). Dept. of Pharmacology) | Saxena, K.K. | Kumar, A.
A new series of 3-(4-(2-(6,8-dibromo-3-(substituted phenyl)-4-oxo- 3,4-dihydroquinazolin-2-yl)methyl) hydrazinyl)thiazol-2-yl)-2- phenylthiazolidin-4-ones were synthesized and their structures were elucidated on the basis of elemental analyses and spectroscopic studies (IR,1H-NMR). All the synthesized compounds 1-32 were screened for their anticonvulsant activity at a dose of 30 mg/kg. The compound 31 was found to be the most potent compound of this series showing 90% protection against MES.
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