In vitro and in vivo anthelmintics activity of Terminalia arjuna bark
2009
Bachaya, H.A. (University of Agriculture, Faisalabad (Pakistan). Dept. of Parasitology) | Iqbal, Z. (University of Agriculture, Faisalabad (Pakistan). Dept. of Parasitology) | Khan, M.N. (University of Agriculture, Faisalabad (Pakistan). Dept. of Parasitology) | Jabbar, A. (University of Agriculture, Faisalabad (Pakistan). Dept. of Parasitology) | Gilani, A.H. (The Aga Khan Univ. Medical Coll., Karachi (Pakistan). Dept. of Biological and Biochemical Sciences) | Islam-ud-Din (University of Agriculture, Faisalabad (Pakistan). Dept. of Mathematics and Statistics)
The present study was carried out to evaluate the anthelmintics activity of Terminalia arjuna (Roxb.) bark locally used as an anthelmintics. Lethal median concentration (LC50 values) of methanolic extract of T. arjuna bark in egg hatch and larval development tests against Haemonchus contortus ova and larva were found to be 645.65 and 467.74 mug mL-1, respectively. In adult motility assay, efficacy of the extract was evident by the mortality of H. contortus at different hours post exposure. In vivo results revealed maximum (87.3%) egg count percent reduction (ECR) in sheep treated with crude methanolic extract @ 3 g per kg body weight on day 11 post-treatment (PT). The data revealed dose-dependent anthelmintics activity both in the in vitro and in vivo studies, thus justifying its use in the traditional medicine system of Pakistan.
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