Effect of lipids originating from egg yolk enriched with conjugated linoleic acid isomers on proliferation of mammary cancer cells
2009
Koronowicz, A.,Uniwersytet Rolniczy, Krakow (Poland). Katedra Zywienia Czlowieka | Dulinska-Litewka, J.,Uniwersytet Jagiellonski Collegium Medicum, Krakow (Poland). Katedra Biochemii Lekarskiej | Pisulewski, P.,Uniwersytet Rolniczy, Krakow (Poland). Katedra Zywienia Czlowieka | Laidler, P.,Uniwersytet Jagiellonski Collegium Medicum, Krakow (Poland). Katedra Biochemii Lekarskiej
The objective of the study was the investigation of the effect of lipids originating from egg yolk enriched with CLA isomers: cis 9, trans 11 and trans 10, cis 12 on proliferation of MCF-7 mammary cancer cells. Egg yolk was enriched with CLA isomers in a natural manner, through feeding laying hens with a mixture of CLA isomers. The cells were incubated with lipids hydrolysate of egg yolk enriched with CLA isomers, within the range of 0.12, 0.36 and 0.73 mg/ml for 24-72 h. There were no toxic effects of the hydrolysate on the cells as indicated by the Cytotoxicity Detection Kit (Roche). The results indicate that lipids of egg yolk with incorporated CLA isomers were more effective in inhibiting MCF-7 cell proliferation as compared to lipids originating from egg yolk without CLA enrichment
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