Quantitative structure-activity relationships to predict antibacterial effect of some benzimidazole derivatives
2008
Podunavac-Kuzmanovic, S.O., Faculty of Technology, Novi Sad (Serbia) | Barna, D.J., Institute of Public Health, Subotica (Serbia) | Cvetkovic, D.D., Faculty of Technology, Novi Sad (Serbia)
The antibacterial activity of some substituted benzimidazole derivatives against Gram negative bacteria Escherichia coli was investigated. The tested compounds displayed in vitro inhibitory activity and their minimum inhibitory concentrations were determined. Quantitative structure- activity relationship has been used to study the relationships between the antibacterial activity and lipophilicity parameter, logP. Lipophilicity parameters were calculated for each molecule by using CS Chem-Office Software version 7.0. Multiple linear regression was used to correlate the logP values and antibacterial activity of benzomidazole derivatives. The results are discussed on the basis of statistical data. The most acceptable QSAR model for prediction of antibacterial activity of the investigated series of benzimidazoles was developed. High agreement between experimental and predicted inhibitory values was obtained. The results of this study indicate that the lipophilicity parameter has a significant effect on antibacterial activity of this class of compounds, thus simplifying design of new biologically active molecules.
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