The visfatin (NAMPT; PBEF1) gene polymorphisms and associations with meat performance traits in three pig breeds kept in the Czech Republic
2009
Zrustova, J.,Mendelova Zemedelska a Lesnicka Univ., Brno (Czech Republic). Ustav Morfologie, Fyziologie a Genetiky Zvirat | Knoll, A.,Mendelova Zemedelska a Lesnicka Univ., Brno (Czech Republic). Ustav Morfologie, Fyziologie a Genetiky Zvirat | Urban, T.,Mendelova Zemedelska a Lesnicka Univ., Brno (Czech Republic). Ustav Morfologie, Fyziologie a Genetiky Zvirat | Cepica, S.,Akademie Ved, Libechov (Czech Republic). Ustav Zivocisne Fyziologie a Genetiky
Visfatin encoded by the NAMPT gene (nicotinamide phosphoribosyltransferase, formerly also known as PBEF - pre-B cell colony-enhancing factor) is suggested to play a role in lipid metabolism and pathophysiology of diabetes mellitus type 2. A new microsatellite SCZ004 was detected within intron 9 of the NAMPT gene. In Czech Large White (n = 95) frequencies of alleles 282, 286, 287, 299, and 304 were 0.02, 0.39, 0.07, 0.04, and 0.48, respectively. Allele 286 was predominant also in Landrace (n = 11) and Black Pied Prestice (n = 11) breeds. Association analysis was carried out between previously reported SNP AM999341:g.669T C in intron 9 of the NAMPT gene and backfat thickness, average daily gain and lean meat content in Czech Large White (n = 215), Black Pied Prestice (n = 96) and Landrace (n = 105). The CC genotype was associated with higher backfat thickness (P less than 0.01) in Black Pied Prestice, however in Czech Large White CC was associated with lower backfat thickness when compared with TT and CT genotypes (P less than 0.05). In Czech Large White, CC genotype was associated with higher lean meat content when compared with CT (not significant) and TT genotype (P less than 0.05) while in Landrace CC had the lowest lean meat content when compared with CT and TT genotypes but only the difference between CC and CTT was statistically significant. In Black Pied Prestice no association with lean meat content was found. Average daily gain was not associated with the SNP in any breed.
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