Effect of Culture Medium on the Inhibitory Activity of Streptomycin
1970
Christian, W.F.K., Food Research Institute,Council for Scientific and Industrial Research
The inhibitory effect of streptomycin on the growth of germinated spores of Bacillus subtilis strain SF 40 is investigated in a number of culture media. The minimum inhibitory concentration of the antibiotic is found to depend on the nature of the medium. Streptomycin is most inhibitory in media least favourable for growth, whereas in those media in which growth is heavy the antibiotic shows reduced inhibitory effect.It is suggested that the differences in the antibacterial activity of streptomycin in the different media may be due to differences in the amounts of glucose, sodium chloride and organic nitrogenous substances in the media.
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