Effect of paracetamol on the pharmacokinetics of danofloxacin in buffalo calves
2009
Gosal, Navjot S. | Rampal, Satyavan | Goyal, Saloni | Chaudhary, Rakesh K.
The pharmacokinetics of danofloxacin on concurrent administration with paracetamol was investigated in buffalo calves. Danofloxacin and paracetamol were given as single intramuscular dose at a rate of 1.25 and 50 mg/kg body weight, respectively. The dosage regimen of danofloxacin when administered with paracetamol was calculated to be 1.73 mgl kg body weight, followed by 1.60 mg/kg repeated at 12h interval. Based on the present results, it is concluded that paracetamol did not significantly affect the pharmacokinetics and dosage regimen of danofloxacin in buffalo calves.
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