Histological alterations in spleen of rabbits induced by ofloxacin
2009
Sethi, R S | Singh, O | Rampal, S | Kaur, R | Sood, N K
The present study was planned to evaluate toxic effects of ofloxacin on spleen, if any after prolonged oral administration. Nine rabbits were equally divided in groups 1, 2 and 3. The rabbits of group 1 and 2 were administrated ofloxacin @20 mg and 40 mg per animal/day orally, respectively, in 2 equally divided doses at 12 hr intervals for 21 consecutive days whereas, the group 3 animals were given normal saline solution which served as control group. The endothelial cells of the central arteriole showed vacuolated cytoplasm and the vessels particularly capillaries were dilated in group 2 without any cellular infiltration. The large pyrinophilic cells around the central arteriole were observed throughout the white pulp and these cells were more in number in group 2. The clumps of Prusian blue positive granules were more in group 2 indicating an effect of ofloxacin administration on the haematopoiesis probably in terms of increased destruction rate of erythrocytes. It was concluded that prolonged administration of ofloxacin in rabbits may result in damage to normal functioning of spleen.
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