Comparison of voiding behavior and urodynamics in two rat models of frequent micturition: Overactive bladder model and cystitis model
2010
Ito, K., Miyazaki Univ. (Japan). Faculty of Agriculture | Iwami, A. | Iida, M. | Katsura, H. | Ikeda, M.
We compared the voiding behavior and the urodynamics in two models of rat frequent micturition, bladder outlet obstruction (BOO) and cyclophosphamide (CYP)-induced cystitis. The urethra of SD rats was partially ligated to make the BOO model. Other rats were injected with CYP (150 mg/kg, i.p.). Frequent micturition was observed 2 to 4 weeks after BOO operation or 48 hrs after injection of CYP. In cystometry experiments, where the bladder was infused with saline and the intravesical pressure was monitored under a conscious and restrained condition, either BOO or CYP-treated rats exhibited enhanced micturition reflex concomitant with occurrence of nonvoiding contractions. Nociceptive responses accompanied each micturition in CYP-treated rats but not in BOO rats. CYP treatment increased the residual urine whereas BOO did not increase it. From the data it is concluded that the enhanced sensitivity to bladder filling contributes to the frequent micturition in both models. However, the existence of residual urine and bladder pain suggests that the mechanisms underlying the frequent micturition may be different between two models.
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