Subacute toxicological study of PG102, a water-soluble extract derived from Actinidia arguta, in SD rats
2008
Hong, E.S. (Helixir Co., Seoul, Republic of Korea) | Kim, M.J. (Helixir Co., Seoul, Republic of Korea) | Kwon, E.J. (Helixir Co., Seoul, Republic of Korea) | Kim, L.H. (Seoul National University, Seoul, Republic of Korea) | Kim, D.H. (Seoul National University, Seoul, Republic of Korea) | Eo, H.K. (Helixir Co., Seoul, Republic of Korea) | Park, E.J. (Helixir Co., Seoul, Republic of Korea) | Kim, S.Y. (Seoul National University, Seoul, Republic of Korea) | Kim, S.H. (Helixir Co., Seoul, Republic of Korea), E-mail: seonhee@helixir.co.kr
It was previously found that PG102, a water-soluble extract derived from Actinidia arguta, was able to modulate Th1/Th2 pathways and suppress IgE production resulting in dramatic amelioration of atopic dermatitis in NC/Nga mouse and hairless rat models. In order to evaluate the subacute toxicity of PG102, female and male SD rats were daily fed with various doses of PG102 for 4 weeks. Six week old SD rats were randomly divided into 4 groups and orally administrated with 100-, 300-, and 1,000-mg/kg of PG102 as well as the vehicle only. At the end of the study, no significant differences in the body and organ weights were observed between control and treated rats of both genders. Hematological and blood chemical analysis showed little differences between the animal groups. Neither gross abnormalities nor histopathological changes were found. PG102 produced little or no subacute toxicity and could be used as a safe nutraceutical for the treatment of individuals with allergic diseases including atopic dermatitis.
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