Rhodiosin, an Antioxidant Flavonol Glycoside from Rhodiola rosea
2009
Kwon, H.J., Korea Research Institute of Bioscience and Biotechnology, Jeongeup, Republic of Korea | Ryu, Y.B., Korea Research Institute of Bioscience and Biotechnology, Jeongeup, Republic of Korea | Jeong, H.J., Korea Research Institute of Bioscience and Biotechnology, Jeongeup, Republic of Korea | Kim, J.H., Korea Research Institute of Bioscience and Biotechnology, Jeongeup, Republic of Korea | Park, S.J., Korea Research Institute of Bioscience and Biotechnology, Jeongeup, Republic of Korea | Chang, J.S., Korea Research Institute of Bioscience and Biotechnology, Jeongeup, Republic of Korea | Kim, M.S., Korea Research Institute of Bioscience and Biotechnology, Jeongeup, Republic of Korea | Rho, M.C., Korea Research Institute of Bioscience and Biotechnology, Jeongeup, Republic of Korea | Lee, W.S., Korea Research Institute of Bioscience and Biotechnology, Jeongeup, Republic of Korea
The EtOAc fraction of Rhodiola rosea ethanolic extracts showed a strong antioxidant activity. Through activity-guided fractionation and purification, we isolated two flavonol glycosides, which were identified as the well known flavonoids, rhodionin (1) and rhodiosin (2). To compare their antioxidant activities, we used an authentic aglycone compound, herbacetin (3). Among the compounds tested, rhodiosin (2) exhibited strong antioxidant activity, with IC∧50 values of 0.21 and 0.15 μM against ㆍOH and ㆍO-₂, respectively. Rhodiosin (2) (100 mg/kg) reduced MDA content in the liver induced by irradiation when given prior to exposure of γ-radiation.
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