Relationship between biofilm formation and the antimicrobial resistance in the Staphylococcus spp. isolated from animal and air
2009
Seo, Y.S., Seoul National University, Seoul, Republic of Korea | Lee, D.Y., Seoul National University, Seoul, Republic of Korea | Kang, M.L., Seoul National University, Seoul, Republic of Korea | Lee, W.J., Seoul National University, Seoul, Republic of Korea | Yoo, H.S., Seoul National University, Seoul, Republic of Korea
Biofilm has been described as a barrier, which produced by microorganisms to survive and protect themselves against various environments, like antibiotic agents. Staphylococcus spp. is a common cause of nosocomial and environmental infection. Thirty-six and thirty-five Staphylococci were isolated from animals and air, respectively. Based on the biofilm forming ability of the bacterium reported in our previous report, relationship between biofilm formation and antibiotic-resistance was investigated in this study. Regarding antibiotics susceptibility, cefazolin was the most effective agent to the bacteria. Strong biofilm-forming Staphylococcus spp. isolates might have a higher antibiotic resistance than weak biofilm isolates regardless of the presence of antibiotic resistance genes (p less than 0.05). This result suggested that the chemical complexity of the biofilm might increase the antibiotic resistance due to the decrease of antibiotic diffusion into cells through the extensive matrix.
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