Analysis of Residual Furan in Human Blood Using Solid Phase Microextraction-Gas Chromatography/Mass Spectrometry (SPME-GC/MS)
2009
Lee, Y.K., Dongguk University, Seoul, Republic of Korea | Jung, S.W., Dongguk University, Seoul, Republic of Korea | Lee, S.J., Korea University, Seoul, Republic of Korea | Lee, K.G., Dongguk University, Seoul, Republic of Korea
For all accurate risk assessment of furan, a potential human carcinogen, levels must be determined in human blood plasma using a simple and robust assay. In this study solid phase microextraction-gas chromatography/mass spectrometry (SPME-GC/MS) Was Used to analyze blood plasma levels of furan ill 100 healthy individuals Who consumed a normal diet. The subjects were 30 to 70 years of age and 51% were women. Ultimately, an analytical method was established tor analyzing furan in human blood. The limit of quantification (LOQ) and furan recovery rate in blood were 1.0 ppb and 104%, respectively. Finally, furan was detected in 21 individuals (13 males, 8 females) with levels ranging up to 17.86 ppb (ng furan/g food).
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