Role of hepatic stellate cell (HSCs) in the development of hepatic fibrosis in cats with polycystic kidney disease (PKD)
2010
Aleksić-Kovacević, S., Faculty of Veterinary Medicine, Belgrade (Serbia) | Kukolj, V., Faculty of Veterinary Medicine, Belgrade (Serbia) | Kureljušić, B., Institute of Veterinary Medicine of Serbia, Belgrade (Serbia) | Marinković, D., Faculty of Veterinary Medicine, Belgrade (Serbia) | Knežević, Đ., Clinical Center of Serbia, Belgrade (Serbia). Institute of Digestive Diseases | Ignjatović, I., Clinical Center of Serbia, Belgrade (Serbia). Institute of Digestive Diseases | Jovanović, M., Faculty of Veterinary Medicine, Belgrade (Serbia) | Knežević, M., Faculty of Veterinary Medicine, Belgrade (Serbia) | Gledić, D., Faculty of Veterinary Medicine, Belgrade (Serbia)
Hepatic stellate cells (HSCs) play a significant role in hepatic fibrogenesis. In the following study we described the distribution of cells that express alpha-smooth muscle actin (alfa-SMA) and desmin in the cat liver with various degrees of fibrosis, as well as the significance of hepatic stellate cells and portal myofibroblasts in the genesis of fibrosis in cats with polycystic kideny disease. Liver samples from 15 necropsied Persian cats were examined. Liver fibrosis was confirmed in cats with terminal stage of chronic cholangiohepatitis and it was characterized by connective tissue septa which divide the liver parenchyma into irregular lobuli. Inflammation in the cat liver is connected with the activation of periductal myofibroblasts. The intensity of immunopositivity of perisinusoidal HSCs to alfa-SMA and desmin varied depending on the degree of fibrosis and was the strongest in livers of cats with cirrhosis.
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