Impaired expression of FoxA3 is not a common cause of Sertoli cell-only syndrome in human infertile patients
2008
Ceh, K., Ljubljana Univ. (Slovenia). Veterinary Fac. | Zorn, B. | Sinkovec, J. | Majdic, G.
FoxA3 knockout mice develop Sertoli cell-only syndrome in adult life. In human infertile patients, the underlying cause of Sertoli cell-only syndrome is often unknown. In the present study, immunoexpression of FoxA3 in human testes biopsy samples was examined to determine whether expression of FoxA3 is impaired in human infertile patients. Twenty six human testes samples (20 with Sertoli cell-only syndrome, 3 with maturation arrest and 3 with normal spermatogenesis) were examined using immunocytochemistry with specific antibodies against FoxA3 protein. All human samples were obtained during diagnostic biopsy procedure because of azoospermia at outpatient infertility clinic. In all 26 human testis samples examined, immunoexpression of FoxA3 was detected in Leydig cells regardless of the histopathological findings. Suggesting that impaired expression of FoxA3 is not a common cause of Sertoli cell-only syndrome in human infertile patients.
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