Comparative pharmacokinetics and PK/PD parameters of five aminoglycosides in goats
2009
Dinev, T., Trakia University, Faculty of Veterinary Medicine, Stara Zagora (Bulgaria). Div. of Pharmacology, Veterinary Physiology and Physiological Chemistry | Urumova, V., Trakia University, Faculty of Veterinary Medicine, Stara Zagora (Bulgaria). Div. of Microbiology, Infectious and Parasitic Diseases | Lyutskanov, M., Trakia University, Faculty of Veterinary Medicine, Stara Zagora (Bulgaria). Div. of Microbiology, Infectious and Parasitic Diseases | Lashev, L., Trakia University, Faculty of Veterinary Medicine, Stara Zagora (Bulgaria). Div. of Pharmacology, Veterinary Physiology and Physiological Chemistry
The pharmacokinetics of gentamicin, tobramycin, amikacin, kanamycin, and apramycin were investigated after single intravenous administration in goats. Their antimicrobial activity against 30 strains of Staphylococcus aureus isolates from goats was also studied. On the base of the pharmacokinetic and pharmacodynamic data, a comparison between antibiotics was made. All 5 antibiotics showed a marked high in vitro antibacterial activity. The lowest MIC90 values were those of amikacin and the highest one was of kanamycin. The ratios of Cmax/MIC showed that amikacin has an advantage of providing the highest values of the concentration/MIC90 ratio, as well of the time providing bactericidal levels, followed by apramycin, whereas the other 3 antibiotics had comparable values, but lower than the first 2 antibiotics. The same interpretation could be made for the area under the curve/MIC90 ratio.
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