Изготовление и контроль качества гипериммунной сыворотки против колибактериоза сельскохозяйственных животных опытной серии
2009
Zajtsev, V.V. | Gorbunova, I.A., Vitebsk Biofactory (Belarus) | Dremach, G.Eh. | Sobolev, V.V. | Biletskij, O.R., Vitebsk State Academy of Veterinary Medicine (Belarus)
In the conditions of the Republic of Belarus there was produced a trial series of hyperimmune serum against livestock animals colibacillosis and there was realized the quality control of the analysed biological preparation. Research results proved that the developed serum was sterile, safe and had high immunogenetic activity. In course of quality control there were considered the following indexes: determination of physiognomy, colour, presence of visually accessible particulate matters; determination of safety and harnfullness; determination of activity; determination of concentration of hydrogen ions; determination of sterility; determination of serum volume in consumption package. For serum production there were used strains E.coli O9, O78, O0, O117, O26, O139, O15, O41, O55, O115, O141, O8, K88, K99, F41, 987P. For the production of trial series there was realized cultivation of Escherichia on the special nutritive media. There used bulls as serum producers
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