Induction of oxidative stress and lipid peroxidation in rats chronically exposed to cypermethrin through dermal application
2009
Raina, Rajinder, Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu, R. S. Pura, Jammu, India | Verma, Pawan K., Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu, R. S. Pura, Jammu, India | Pankaj, N.K., Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu, R. S. Pura, Jammu, India | Prawez, Shahid, Indian Veterinary Research Institute, Izatnagar, India
Present study was undertaken to study the effect of cypermethrin on oxidative stress after chronic dermal application. The insecticide was applied dermally at 50 mg/kg body weight in different groups of Wistar rats of either sex weighing 150∼200 g. Significant (p less than 0.05) increase in catalase activity was observed after 30 days of exposure. However, the superoxide dismutase activity declined significantly after 60 days of exposure. The activity of glutathione peroxidase and blood glutathione levels declined significantly (p less than 0.05) after 30 days of cypermethrin dermal application. However, the activity of glutathione S-transferase increased significantly (p less than 0.05) in all groups after 60 days of dermal exposure. Significant increase in lipid peroxidation was observed from 30 days onwards and reached a peak after 120 days of application.
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