Microbial Metabolism of Yangonin, a Styryl Lactone from Piper methysticum (Kava)
2010
Kim, J.H., Korea Ocean Research and Development Institute, Ansan, Republic of Korea | Kim, H.J., Chonnam National University Medical School, Gwangju, Republic of Korea | Lee, I.S., Chonnam National University, Gwangju, Republic of Korea
Microbial metabolism studies of yangonin (1), a major styryl lactone from Piper methysticum, have resulted in the production of three hydroxylated metabolites (2-4). The chemical structures of these compounds were elucidated to be 4-methoxy-6-(12-hydroxystyryl)-2-pyrone (2), 4-methoxy-6-(11,12-dihydroxystyryl)-2-pyrone (3), and 4,12-dimethoxy-6-(7,8-dihydroxy-7,8-dihydrostyryl)-2-pyrone (4) on the basis of the chemical and spectroscopic analyses. The compounds 3 and 4 are reported herein as microbial metabolites of yangonin for the first time.
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