Anti-inflammatory effect of Pentalonia binghamiae in LPS-induced macrophages is mediated by suppression of iNOS and COX-2
2010
Eun-Jin, Y. (Jeju Biodiversity Research Inst. (Korea)) | Ji-Young, M. (Cheju National Univ. (Korea). Jeju Seaweed Industry Development Agency) | Min-Jin, K. (Cheju National Univ. (Korea). Jeju Seaweed Industry Development Agency) | Kim, D.S. (Cheju National Univ. (Korea). Jeju Seaweed Industry Development Agency) | Lee, W.J. (Cheju National Univ. (Korea). Jeju Seaweed Industry Development Agency) | Lee, N.H. (Cheju National Univ. (Korea). Dept. of Chemistry) | Chang-Gu, H. (Cheju National Univ. (Korea). Research Group for Beauty and Cosmetics)
A number of seaweed species are used as traditional medicine in different parts of the world. However, very few data on the anti-inflammatory effect of seaweed have been published. Pentalonia binghamiae (Miyeoksoi), a brown alga, is a traditional food in the southern regions of the Korea peninsula. In this study, the anti-inflammatory effects of the ethyl acetate extracts of P. binghamiae were evaluated on lippolysaccharide (LPS)-treated RAW 264.7 macrophages. Our results supports that P. binghamiae potently inhibited LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production, exhibiting IC50 values of 38.8 and 9.3 mug/mL. Consistent with these findings, P. binghamiae reduced the LPS-induced expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) at the protein level in a concentration-dependent manner, as determined by Western blotting.
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