In vitro comparison of sustained release hydroxypropylmethyl cellulose and lipid-based matrix systems of diltiazem HCI
2010
Adnan, S. (Islamia Univ., Bahawalpur (Pakistan). Dept. of Pharmacy) | Nisar-ur-Rahman (Islamia Univ., Bahawalpur (Pakistan). Dept. of Pharmacy) | Ahmed, S. (Islamia Univ., Bahawalpur (Pakistan). Dept. of Pharmacy) | Khan, S.M. (Islamia Univ., Bahawalpur (Pakistan). Dept. of Pharmacy) | Saeed-ul-Hassan, S. (Punjab Univ., Lahore (Pakistan). Univ. Coll. of Pharmacy)
A polyglycolised glyceride lipid carrier, Gelucire 50/13 (G50/13) was used to develop sustained capsules while high viscosity grade HPMC was used to form sustained release tablets of diltiazem HCI. Both and G50/13 based formulations prepared with increasing polymer to drug ratios showed a substantial decrease release rate. However, G50/13 based matrix containing stearyl alcohol caused greater retardation in release compared to G50/13 and provided more linear release profile which was chosen for comparison with HPMC tablets. The drug release from chosen formula of gelucire was stable at ambient temperature (25 degree C) after aging months and essentially independent of pH. Moreover, drug release rate of both sustained release tablets and capsules were found to be comparable with reference product, Herbesser SR.
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