Obestatin induces testosterone but not prolactin secretion in male sprague dawley rats
2010
Jahan, S. (Quaid-i-Azam Univ., Islamabad (Pakistan). Dept. of Animal Sciences) | Ahmed, S. (Quaid-i-Azam Univ., Islamabad (Pakistan). Dept. of Animal Sciences) | Taqvim, N. (Quaid-i-Azam Univ., Islamabad (Pakistan). Dept. of Animal Sciences) | Hizbullah
The present study was designed to investigate the in vivo effect of an anorexigenic gut peptide obestatin on plasma testosterone and Prolactin secretion in adult male Sprauge Dawley rats. One group of animals served as control (n=5), while the treatment group (n=5) received a single i.v. dose of 8 nmol/Kg of obestatin. Blood samples (200mul-250 mul) were collected at -10, 0, 10, 20, 30 and 40 min of treatment. In treated group obestatin caused a significant (p less than 0.05) increase in plasma testosterone concentrations at 20 minutes. However, at 30 and 40 min post treatment, the plasma testosterone concentrations declined to non-significantly (P greater than 0.05) higher values. A significant (P less than 0.05) increase in plasma testosterone concentrations was observed after treatment, compared to that before treatment. Obestatin showed no profound effect on plasma prolactin concentration in all the treated groups. It was concluded that obestatin i.v. infusion leads to i
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