Cytogenetic changes in human lymphocytes induced by alphachlorhydrine
2010
Teodorović, R., Faculty of Veterinary Medicine, Belgrade (Serbia) | Stanimirović, Z., Faculty of Veterinary Medicine, Belgrade (Serbia) | Radenković-Damnjanović, B., Faculty of Veterinary Medicine, Belgrade (Serbia) | Vučinić, M., Faculty of Veterinary Medicine, Belgrade (Serbia) | Janković, Lj., Faculty of Veterinary Medicine, Belgrade (Serbia) | Đorđević, M., Faculty of Veterinary Medicine, Belgrade (Serbia) | Mirilović, M., Faculty of Veterinary Medicine, Belgrade (Serbia)
This paper deals with the results of the investigation carried out with regard to genotoxic properties of Alphachlorhydrine administered at doses of 7.5, 15 and 30 mg/kg of cell culture - human lymphocytes, during an exposition time of three days, under in vitro conditions. The assessment of the genotoxic effects of the tested chemosterilants was performed on the basis of numerical and structural aberrations in three experimental groups, in addition to one control group for each dose. On the basis of the obtained results it can be concluded that Alphachlorhydrine, administered in the abovementioned doses, induced genotoxic effect on human lymphocyte cells.
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