Blood concentrations of thyroid hormones and lipids and histological changes in the liver in dairy cows in postparturient period
2009
Đoković, R., Faculty of Agronomy, Čačak (Serbia)
The triiodthyronine (T3), thyroxine (T4), glucose, free fatty acids (FFA), triacylglycerols (TAG), and total cholesterol concentrations were estimated in the blood serum and content of lipids in the liver in healthy (n=10) and ketotic (n=10) dairy cows in the postparturient period. Pathohistological examination of liver tissues showed statistically significant higher lipid infiltration in ketotic cows compared to healthy ones. Biochemical examination of blood serum showed significantly higher values of free fatty acids in ketotic cows such as significantly lower concentration of glucose, triacylglycerols, total cholesterol, triiodthyronine, and thyroxine compared to values of these parameters in the blood serum in healthy cows. Significant increase of concentration of free fatty acids, such as positive correlation between the free fatty acids in blood and the content of lipids in liver in ketotic cows compared to the healthy ones, as well as pathohistological report, shows that during intensive lipomobilisation newly synthetized triacylglycerols accumulated in the hepatocytes. In ketotic cows hypothyroidal status is established and it can be a significant factor in the development of fatty liver.
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