Antiproliferative activity of methanolic extract from Teucrium scordium L. on HCT-116 cell line | Antiproliferativna aktivnost metanolnog ekstrakta biljke Teucrium scordium L. na HCT-116 ćelijskoj liniji
2011
Ćurčić, M.G., Prirodno-matematički fakultet, Kragujevac (Serbia) | Stanković, M.S., Prirodno-matematički fakultet, Kragujevac (Serbia) | Đačić, D.S., Prirodno-matematički fakultet, Kragujevac (Serbia) | Topuzović, M.D., Prirodno-matematički fakultet, Kragujevac (Serbia) | Marković, S.D., Prirodno-matematički fakultet, Kragujevac (Serbia)
In the present investigation we examined antiproliferative effect of methanolic extract from Teucrium scordium in vitro on HCT-116 cell line. In order to determine antiproliferative effect we used MTT viability assay and AO/EB assay on fluorescence microscope. The IC50 values were 17.04 after 24h and 59.02 after 72h. Results also showed that 48.55% of cells were in early and 44.20% of cells were in late apoptosis. Our data showed that T. scordium presents important source biologically active substances which have potently antiproliferative activity on cancer cells.
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