Chiral recognition of α-,β- and γ-cyclodextrin to Temazepam by computer simulation screening___ | α-•β-•γ-环糊精对Temazepam手性识别的分子模拟筛选_
2011
Liu Tiebing, Zhejiang University of Science and Technology, Hangzhou (China) | Zhang Zhiqiang, China Medicine University, Nanjing (China), Teaching and Research Office of Analytical Chemistry | Pan Hejian, China Medicine University, Nanjing (China), Teaching and Research Office of Analytical Chemistry
Chinese. 在相同的模拟条件下，采用α-、β-和γ-CD作为手性拆分试剂，对Temazepam手性拆分进行了模拟研究。结果表明，不同大小的环糊精在识别Temazepam对映体分子时有不同的手性识别能力：α-CDγ-CDβ-CD。说明在这3种环糊精中，α-CD最适合作为溶剂对Temazepam对映异构体进行拆分，计算机模拟筛选为今后合理选用手性拆分试剂提供了理论依据。_
Show more [+] Less [-]English. Under the same simulation conditions, Temazepam chiral separation was simulated and studied with α-,β- and γ-CD as the reagents. Results indicated that the cyclodextrin with different molecular sizes had different capacity in the chiral recognition of Temazepam enantiomers, which could be shown as α-CDγ-CDβ-CD. Among the three cyclodextrins,α-CD was the most suitable reagent for the separation of Temazepam enantiomers, computer simulation screening provided theoretical basis for the rational use of chiral separation reagents in the future._
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