Interaction of Coccinia indica with glibenclamide in alloxan induced diabetic rats.
2011
Jose, Eliza | Usha, P.T.A
Interactive effect of ethanolic extract of Coccinia indica leaves with glibenclamide (oral hypoglycemic agent) on hypoglycaemic, hypolipidemic and antioxidant effect in alloxan induced diabetic rats was studied. The diabetic rats were administered with C. indica leaf extract at the dose of 100, 150 and 200 mg/kg body weight in combination with glibenclamide at the rate of 0.125 mg/kg. Blood glucose, serum cholesterol and triglyceride were estimated at 15 days intervals and liver glycogen, reduced glutathione and lipid peroxides in tissues at the end of the experiment. All the treatment groups showed significant lowering of blood glucose after 45 days of treatment when compared to the diabetic control. Serum cholesterol and triglycerides also returned to normal levels after 45 days of treatment. Reduced glutathione and lipid peroxide levels were also comparable with that of normal control at the end of the treatment. None of the treatment group showed any severe hypoglycaemia or other toxic effects and the combination of C. indica at the rate of 200 mg/kg with glibenclamide produced the most significant antidiabetic effect. The results suggested that interaction of C. indica with glibenclamide can produce significant hypoglycaemic, hypolipidemic and antioxidant effect in diabetic rats and can be used safely in the treatment of diabetes.
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