Dendrotoxin-κ suppresses tumor growth induced by human lung adenocarcinoma A549 cells in nude mice
2011
Jang, S.H., Seoul National University, Seoul, Republic of Korea | Ryu, P.D., Seoul National University, Seoul, Republic of Korea | Lee, S.Y., Seoul National University, Seoul, Republic of Korea
Voltage-gated K+ (Kv) channels have been considered to be a regulator of membrane potential and neuronal excitability. Recently, accumulated evidence has indicated that several Kv channel subtypes contribute to the control of cell proliferation in various types of cells and are worth noting as potential emerging molecular targets of cancer therapy. In the presene: study, we investigated the effects of the Kv1.1-specific blocker, dendrotoxin-κ (DTX-κ), on tumor formation induced by the human lung adenocarcinoma cell line A549 in a xenograft model. Kv1.1 mRNA and protein was expressed in A549 cells and the blockade of Kv1.1 by DTX-κ, reduced tumor formation in nude mice. Furthermore, treatment with DTX-κ significantly increased protein expression of p21∨Waf1/Cip1, p27∨Kip1 and p15∨INK4B and significantly decreased protein expression of cyclin 03 in tumor tissues compared to the control. These results suggest that DTX-κ jas anti-tumor effects in A549 cells through the pathway governing G1-S transition.
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