Effect of Fermented Cucumber Beverage on Ethanol Metabolism and Antioxidant Activity in Ethanol-treated Rats
2011
Lee, H.I., Sunchon National University, Sunchon, Republic of Korea | Seo, K.I., Sunchon National University, Sunchon, Republic of Korea | Lee, J., Sunchon National University, Sunchon, Republic of Korea | Lee, J.S., Sunchon National University, Sunchon, Republic of Korea | Hong, S.M., Sunchon National University, Sunchon, Republic of Korea | Lee, J.H., Sunchon National University, Sunchon, Republic of Korea | Kim, M.J., Daegu Polytechnic College, Daegu, Republic of Korea | Lee, M.K., Sunchon National University, Sunchon, Republic of Korea
Cucumber fermentation has been used as a means of preservation. This study was performed to investigate the effects of fermented cucumber beverage (CF) containing beneficial materials for an ethanol hangover based on Hovenia dulcis (SKM) on ethanol-induced hepatotoxicity. Male Sprague-Dawley rats were randomly divided into three groups: ethanol control, ethanol plus SKM, and ethanol plus CF＋SKM. SKM or CF＋SKM was orally administered at a dose of 7 mL/kg body weight once per day for 5 weeks. Control rats were given an equal amount of water. CF＋SKM significantly lowered plasma ethanol levels, whereas SKM tended to decrease the levels compared to the control. Both SKM and CF＋SKM significantly lowered the plasma acetaldehyde levels and serum transaminase activities compared to those in the control. SKM and CF＋SKM did not affect hepatic alcohol dehydrogenase activity; however, it significantly inhibited cytochrome P450 2E1 (CYP2E1) activity. Hepatic aldehyde dehydrogenase (ALDH) activity was significantly higher in the SKM and CF＋SKM groups than that in the control group. Plasma acetaldehyde concentration was significantly correlated with hepatic CYP2E1 (r=0.566, p less than 0.01) activity and ALDH (r=-0.564, p less than 0.01) activity. Hepatic superoxide dismutase and catalase activities as well as glutathione content increased with the SKM and CF＋SKM administration, whereas lipid peroxide content decreased significantly. Furthermore, SKM and CF＋SKM lowered plasma and hepatic lipid content and lipid droplets compared to those in the control group. These results indicate that SKM and CF+SKM exhibit hepatoprotective properties partly by inhibiting CYP2E1 activity, enhancing ALDH activity and stimulating the antioxidant defense systems in ethanol-treated rats.
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