Overeni metody a testace ucinnosti antifasciolik proti juvenilnim stadiim motolice Fasciola hepatica u laboratornich mysi.
1991
Babicek K. | Danek J.
Lethality of mice experimentally infected by the metacercariae of F. hepatica was determined. Starting body weights of mice were 11-12 g and 30-35 g respectively; infection doses were 5, 7 or 10 metacercariae respectively. After the dose of five metacercariae 33.3 per cent, or 58.3 per cent of infected mice died; respective percentages after administration of the doses of seven and ten metacercarie were 50 per cent, or 66.7 per cent, and 83.3 per cent, or 91.7 per cent. Almost all losses were recorded in the period from day 23 to day 35 after infection (DAI). The efficacy of the substances clorsulon, closantel, oxyclozanide, rafoxanide was investigated in the control of juvenile stages of the liver fluke F. hepatica in mice infected by the dose of ten metacercariae. The substances were administered per os on DAI 13 and 14 at the doses from 50 mg to 400 mg per kg live weight/day. The efficacy of clorsulon was higher than 90 per cent after administration of the doses 100 mg and 200 mg per kg live weight, 100 per cent efficacy being reached after administration of the dose 400 mg per kg live weight. The efficacy of diamphenethide doses 200 mg per kg live weight and 400 mg per kg live weight reached 77.8 per cent and 100 per cent, respectively. The products closantel, rafoxanide and oxyclozanide did not show standard efficacy in the control of juvenile stages of the liver fluke F. hepatica. The liver tissue of cured mice was found to be regenerated at the end of the tests, i. e. on DAI 22. The laboratory model of F. hepatica in mice can be used for substance screening applying the described method.
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