Effect of beta-adrenergic agonist (Clenbuterol) on skeletal muscle protein turnover in broiler chicks fed either low or adequate protein diet.
1994
Hamano Y. | Kobayashi S. | Terashima Y.
This experiment was conducted in order to determine the effects of clenbuterol on skeletal muscle protein turnover in broiler chicks fed either a low or adequate protein diet. The 21 day-old female broiler chicks were divided into 4 groups of 6 birds and fed a low (CP, 11%) or adequate (CP,22%) protein diet with or without 1 ppm of clenbuterol during the 12-day experimental period. Excreta were collected for the last 3 days of the experimental period in order to determine 3-methylhistidine (3MH) excretion. The clenbuterol treatment decreased (P<0.01) feed intake and body weight gain in the low protein group, and also tended to decrease these values in the adequate protein group. Feed efficiency was decreased by the supplementation of clenbuterol in both dietary protein groups. Clenbuterol did not affect abdominal fat weight or protein and fat content in the breast muscle. The muscle protein breakdown rate (Kd) estimated from 3MH excretion decreased (P<0.05) due to clenbuterol supplementation to the adequate protein diet, but did not change in the low protein diet. The protein synthesis rate (Ks) was not effected by clenbuterol supplementation to either diet. These results suggest that the stimulatory effect of clenbuterol on chicken growth might depend on dietary protein level, and that clenbuterol can reduce muscle protein breakdown rate when chicks are fed an adequate protein diet.
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