Effects of essential fatty acid deficiency on gamma-glutamyltranspeptidase activity of rat pancreas.
1992
Valentich M.A. | Monis B.
The effect of feeding rats with an essential fatty acid-deficient or -sufficient diet for a total of 29 1/2 weeks (1 1/2 weeks of pregnancy, 4 weeks of lactation and 24 weeks postweaning) on gamma-glutamyltranspeptidase activity and fatty acid composition of pancreas were determined. Enzyme activity of essential fatty acid-deficient rats was significantly higher than in controls. In a group of 24-week-old, essential fatty acid-deficient rats, the sufficient diet was fed for 8 weeks. Pancreatic gamma-glutamyltranspeptidase activity and fatty acid composition were restored to normal, suggesting a modulating effect of the diet. The results indicated that elevated gamma-glutamyltranspeptidase activity of essential fatty acid-deficient rat pancreas was reverted to normal by feeding an essential fatty acid-sufficient diet.
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