Effects of islet hormones on amylase release from the exocrine pancreas of mouse.
1994
Katoh K. | Maeda K.
The present experiment was carried out to investigate the effects of islet hormones on amylase release from exocrine pancreas of mouse. The maximal amylase release evoked by acetylcholine application from the pancreatic segments isolated from 1 hr after intraperitoneal injection of glucagon of insulin was significantly smaller than that of physiological saline or somatostatin. This might be due to the reduction of the tissue amylase content, since the amylase content in the segments from glucagon- or insulin-injected mouse was significantly smaller than that in the segments from saline- or somatostatin- injected mouse. This reduction in amylase content was partly but significantly restored by the intraperitoneal preinjection of atropine sulfate or hexamethonium bromide. The morphological features clearly showed that the number of zymogen granules in the acinar cells from insulin-injected mouse was very scant compared with the saline-injected mouse. In addition, glucagon only could increase the basal and endogenous ACh-stimulated amylase release in the segments from non-injected mouse. From these results, it is concluded that glucagon accelerates amylase release in vivo and in vitro, while insulin does only in vivo, through in part the cholinergic nerve excitation in mouse exocrine pancreas.
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