1,2,4-Triazolo[1,5-a]pyrimidine-2-sulfonanilide herbicides: influence of alkyl, haloalkyl, and halogen heterocyclic substitution on in vitro and in vivo biological activity.
1992
Kleschick W.A. | Costales M.J. | Gerwick B.C. | Holtwick J.B. | Meikle R.W. | Monte W.T. | Pearson N.R. | Snider S.W. | Subramanian M.V. | VanHeertum J.C.
An outline of the synthetic routes used to prepare a series of alkyl, halo and haloalkyl substituted 1,2,4-triazolo[1,5a]-pyrimidine-2-sulfonanilides is presented. The in vitro activity against acetolactate synthase and the herbicidal activity of these analogs is discussed. The evaluation of these activities led to the selection of DE-498 as a candidate for development as a broadleaf herbicide for soybeans, corn and other crops.
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