G2 studies of antimutagenic potential of chemopreventive agent curcumin in Allium cepa root meristem cells
2008
Palani Kumar, L., The Madura College, Madurai (India). Research Centre and Post Graduate Studies in Botany | Paneerselvam, N., The Madura College, Madurai (India). Research Centre and Post Graduate Studies in Botany
Turmeric has long been used as a spice and food colouring agent in Asia. Curcumin is one of the active principles in Turmeric. In this research the antimutagenic potential of curcumin in Allium cepa root meristem cells was evaluated. The root tip cells were treated with sodium azide at 200 microg/ml and 300 microg/ml for 1h. Curcumin was given at 5, 10 and 20 microg/ml for 18h (one cell cycle), prior to sodium azide treatment. The tips were squashed after colchicine treatment and the cells were analyzed for chromosome damage and mitotic index. Curcumin did not induce chromosomal aberration in Allium cepa root tip cell. Sodium azide alone induced chromosomal aberrations significantly with increasing concentrations. The chromosomal aberrations were significantly reduced in root tips cells pretreated with curcumin. The study reveals the antimutagenic potential of curcumin against sodium azide induced chromosomal aberrations.
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