Scientific Opinion on Flavouring Group Evaluation 7, Revision 4 (FGE.07Rev4):Saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids from chemical group 5
2012
<p>The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 49 flavouring substances in the Flavouring Group Evaluation 07, including additional five substances in this Revision 4, using the Procedure in Commission Regulation (EC) No 1565/2000. Since the publication of the last revision of this FGE, the EFSA has been requested to evaluate five additional substances, 2,6-dimethylocta-1,5,7-trien-3-ol, octa-1,5-dien-3-ol, undeca-1,5-dien-3-ol, pseudo-ionone and 3,3,6-trimethylhepta-1,5-dien-4-one [FL-no: 02.145, 02.194, 02.211, 07.198 and 07.204], which have been included in the present revision of FGE.07. None of the 49 substances were considered to have genotoxic potential. The substances were evaluated through a stepwise approach that integrates information on the structure-activity relationships, intake from current uses, toxicological threshold of concern, and available data on metabolism and toxicity. The Panel concluded that all 49 substances do not give rise to safety concerns at their levels of dietary intake, estimated on the basis of the MSDI approach. Besides the safety assessment of the flavouring substances, the specifications for the materials of commerce have also been considered. For three substances [FL-no: 02.194, 02.211 and 02.255] the stereoisomeric compositions have not been given and for one substance [FL-no: 07.156] information on the composition of the stereoisomeric mixture is lacking.</p>
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