Researches on vicinal immune responses in canine leptospirosis

English. Leptospirosis is a zoonosis of constant importance as causative microbial agent, maintained by subclinical infections in wild and domestic animals. Currently, for active immunization in dogs is used an inactivated vaccine, produced by specialized companies in different countries. The vast majority are polyvalent vaccines, which include the two leptospire serovars (Leptospira canicola and Leptospira icterohaemorhagiae) and viral antigens for prevention of infectious hepatitis Rubarht, Carre's disease, coronavirus and parainfluence. Specific immunity induced by this inactivated vaccine, is active, individual, installs in 10 to 21 days after administration, lasting a variable time (4-6 months) and never causes a 100% protection. This paper aims to investigate how this immune response in carnivores and its protection.

Romanian; Moldavian; Moldovan. Leptospiroza este o zoonoza de permanenta actualitate, intrucat agentul microbian cauzativ este mentinut, prin infectii subclinice, la animale salbatice si domestice. In prezent, pentru imunizarea activa a cainilor, sunt utilizate o gama larga de vaccinuri inactivate, foarte eficace, produse de firme specializate din diverse tari. In marea lor majoritate sunt vaccinuri polivalente, care includ, pe langa cele doua serovariante de leptospire, intalnite frecvent la canide (Leptospira canicola si Leptospira icterohaemorhagiae), si antigene virale pentru prevenirea hepatitei contagioase Rubarht, boala lui Carre, coronavirus ºi parainfluenta. Imunitatea specifica indusa de vaccin, inactivat este activa, individuala, se instaleaza in 10-21 de zile de la administrare, dureaza un timp variabil (4-6 luni) si niciodata nu determina o protectie de 100%. Prezenta lucrare are rolul de a investiga modul de instalare a raspunsului imun la carnivore, precum si protectia acestuia.