The biochemical protective role of some herbs against aflatoxicosis in ducklings: I. Turmeric
2011
Ayoub, M. M., Central Laboratory of Residue Analysis of Pesticide Residues and Heavy Metals in Food, Dokki-Cairo (Egypt) | El-Far, A. H. | Taha, N. M.
Objective - The aim of this study was planned to throw the light on the hepatotoxic effects of aflatoxin in duck and to evaluate the effects turmeric (Curcuma longa ground roots) for protection against aflatoxicosis and to explore if they can decrease the aflatoxin production by Aspergillus flavus toxigenic strain on poultry diet. Design - in vitro and in vivo experimentation, malondialdhyde (MDA), Glutathione (GSH) and aflatoxin residues. Results - Aflatoxin (AF) from Aspergillus flavus toxigenic strain was selected as a potent and widely distributed hepatotoxin that induces much health and economic hazards in animal and human. Aspergillus flavus was cultivated on rice to produce the aflatoxin that is used in the present study. Pekin ducklings were allotted to control, aflatoxin treated, turmeric and aflatoxin and turmeric groups. Total proteins, albumin, alanine aminotransferase (ALT) (EC 2.6.1.1) and aspartate aminotransferase (AST) (EC 2.6.1.2), cholesterol and triacylglycerols were measured in serum. The levels of hepatic Malondialdhyde and Glutathione levels and aflatoxin residues were also measured. Conclusions - From the obtained results, it can conclude that aflatoxin has hepatotoxic effects through decrease of total proteins, albumin and glutathione. Moreover, increase ALT, AST, cholesterol, triacylglycerols and lipid peroxidation levels. In addition, aflatoxin induced histopathological changes of liver and residues of aflatoxin were measured. Addition of turmeric to duckling's ration were induced a protective effect against aflatoxicosis. So, we advice to use turmeric as a feed additive in poultry farms.
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