Resveratrol Inhibits Lipopolysaccharide-induced Phagocytotic Activity in BV2 cells
2012
Park, E.T., Chosun University, Gwangju, Republic of Korea | Kim, D.K., Chosun University, Gwangju, Republic of Korea | Chun, H.S., Chosun University, Gwangju, Republic of Korea
The inhibitory effects of resveratrol, a natural bioactive polyphenolic phytoalexin rich in grape, on lipopolysaccharide (LPS)-induced microglial activation and its beneficial effects on dopaminergic neurodegeneration were studied. Resveratrol dose-dependently suppressed LPS-induced nitric oxide production and the expression of inducible NO synthase (iNOS) in BV-2 microglial cells. Furthermore, resveratrol (1 μM) significantly blocked BV2 microglial phagocytosis induced by LPS (0.1 ㎍/mL). Although the conditioned media from LPS-stimulated BV2 cells caused the SN4741 dopaminergic neuronal cell death, that from resveratrol-pretreated BV2 cells did not diminish the viability of SN4741 cells. These results suggest that resveratrol can prevent neuronal death possibly through the modulation of phagocytosis and microglial activation.
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