Antioxidant and hepatoprotective effects of Parinari curatellifolia root
2013
Atawodi, S.E. (Ahmadu Bello Univ., Zaria (Nigeria). Dept. of Biochemistry) | Yakubu, O.E. (Ahmadu Bello Univ., Zaria (Nigeria). Dept. of Biochemistry) | Umar, I.A. (Ahmadu Bello Univ., Zaria (Nigeria). Dept. of Biochemistry)
The antioxidant and hepatoprotective effects of Parinari curatellifolia Planch. ex Benth root methanolic extract on rats administered single (0.6 mL/kg) and repeated doses of carbon tetrachloride (0.3 mL/kg) were investigated in male albino rats allotted into six groups of five animals each. Three days pre-treatment with extract (5 mg/kg), resulted in significant decrease in malondialdehyde (MDA), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and bilirubin as well as increase in superoxide dismutase (SOD) and catalase in CCl4-treated rats. Similarly, long term treatment with the extract at 2.5 mg/kg daily doses following 72-h administration of CCl4 resulted in significant decrease in levels of MDA, AST, ALT, bilirubin, as well as increase in SOD and catalase. These results show that methanolic extract of the roots of P. curatellifolia possess significant antioxidant and hepatoprotective effects on acute and chronic liver injuries.
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