Testicular toxicity induced by deltamethrin in albino mice
2012
Rashid, A. (Government Science Coll., Lahore (Pakistan). Dept. of Zoology) | Asmatullah (Punjab Univ., Lahore (Pakistan). Dept. of Zoology) | Zara, N. (Government Science Coll., Lahore (Pakistan). Dept. of Zoology) | Ara, C.
The objective of this study was to investigate the toxic potential of deltamethrin on the development of testis in mice. The histopathological changes induced by deltamethrin were assessed in two groups. Different concentrations of deltamethrin 0.00, 3.00 and 5.00 mug/g Bw were used repeatedly for 15 and 30 days. After dosing mice were acclimatized for some days. The testes were recovered at 45th day from treatment. Histological examinations revealed significant alterations in the testes of all dose groups. Histological abnormalities observed were hyalinization, vacuolization, exfoliated spermatocytes, dilation and tubular deformity, tubular destruction and atrophy, cellular vacuolated degeneration, apical sloughing and multilayered seminiferous epithelia with late spermatids lining the lumen of the seminiferous tubules in the testis. The observed pathological changes were dose concentration and exposure time duration dependent. It is concluded that the concentrations of deltamethrin used during the present study proved toxic in mice.
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