Larva micrations in mice following infection with Emryonated eggs of Ascaridia galli
2009
El-Mabgoub, A.F. | Ammar, Kh. N.A.
the aim of the present work to examine the possibility of larval migration in Ascaridia galli infection in mice as a model. The females of Ascaridia galli worms were isolated from the intestine of infected chickens. Their eggs were obtained from the intestine of infected chickens. Then allowed to embryonate and develop into infected larvae. A total of 40 male Albino mice were used in this study, 35 were orally infected each with 1000 emryonated eggs. The animals were sacrificed at one, two, three, four, five, six and seven weeks post infection. In addition, five more mice (uninfected) served as a control group. Histological examination of tissue specimens (liver, lung, brain, and intestine) was done. Mononuclear inflammatory cell infiltrate started to appear in the different organs at the 3rd week of post infection. Its intensity increased gradually between the 4th and 7th week of post infections. The lamina proporia of the small intestine was studded with many larvae at the 3rd week of post infection. Migrating larvae were seen in the brain tissues (6th week of post infection) with necrotic areas. The ability of Ascaridia galli to induce larval migrations in mice raises the concern of a possible similar situation in human ingesting food or water contaminated by feaces of infected chickens or other birds.
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