T-cells proliferation by stimulated polymorphuclear neutrophils in presence of superantgen
2009
Abdel-Salam, B.A.
Polymorphonuclear neutrophils (PMN) were originally described as short lived and terminally differentiated phagocytes that contribute only to the innate immune response. Recent evidence of PMN cytokine production and expression of numerous cell surface proteins has suggested that PMN are likely to influence adaptive responses and may satisfy the criteria of antigen presenting cells. There are three types of IL-2R (a, P and y). Only 1L-2R a and y were detected in stimulated PMN. In this study IL-2110 chain was detected on PMN using a confocal laser microscopy examination. This prompted us to define IL-2 participation in some biological properties of PMN. We have previously shown that normal human PMN contain cytoplasmic stores of molecules associated with antigen presentation and Tcell costimulation. Major histocompatibility complex class 11 is the important one of these molecules. These cytoplasmic molecules were found to translocate to the cell surface with different stimuli. In this study, IL-2 in vitro activation of PMN had acquired MHC class 11 on the surface and at the gene level. Some studies had suggested that neutrophils might be played a role in antigen presentation. In support of this hypothesis it had been shown that co-cultivation of IL2 stimulated PMN with autologous T-cells and in the presence of Staphylococcus Aureus enterotoxin A (SEA) induced T-cell proliferation.
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