Effect of fresh garlic on glutathione and liver tumor-marker enzyme activities in rats induced with hepatocarcinogen
2001
Rabeta Mohd Salleh | Asmah Rahmat | Nawalyah Abd. Ghani | Siti Muskinah Mansor
Over the past half century experiments on laboratory animals, and more recently studies in human populations have generated on abundant data pertaining to the role of dietary components in the etiology and prevention of cancer. For example, previous studies have used bioactive compounds in garlic as anti-cancer agent. The objective of this study is to determine the effect of 4 different doses of fresh galic in rats treated with diethylnitrosamine (DEN) and 2-acetylaminofluorene (AAF) as promoters of liver cancer in vivo by determining the glutathione (GSH) level and tumor-marker enzyme activities in the liver such as glutathione S-transferase (GST) and uridine diphosphoglucuronyl transferase (UDPGT). The GST result showed no significant differrence between control and low dose of garlic (50 mg/kg body weight) group whereas high doses of garlic (100 mg/kg body weight). In conclusion, most of the doses of garlic caused the decreases of GST and UDPGT activities and also the concentration of GSH. The optimum dose of the garlic to decrease the severity of hepatocarcinogenesis seems to be 50 mg/kg body weight.
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