Assessment of synergistic and/or prooxidant activity of polyphenol mixtures at different molar ratios
2011
Choueiri, L.
The behaviour of 4 known antioxidants (Quercetin, Ascorbic acid, Catechin and Caffeic acid) and their mixtures at different ratios was studied in view of elaborating predictions over an eventual prooxidant or synergistic activity. The measurements were carried out using Luminol Chemiluminescence. The Co (II) EDTA Luminol Chemiluminescence showed that the mixture of Quercetin and Ascorbic acid at ratio 2:1 had the most pronounced antioxidant activity, while that of Quercetin and Caffeic acid at ratio 1:2 showed the least antioxidant activity, which may be interpreted as a strong propensity for prooxidant activity. The LC-MS analysis for the two mixtures revealed a significant amount of unoxidized Quercetin in the case of Quercetin with Ascorbic acid, whereas in the case of Quercetin with caffeic acid this amount was negligible. This observation supports the fact that the first combination was more antioxidant than the second, through efficient Quercetin recycling (reduction of the quinone by AA; redox cycling of quinones).
Show more [+] Less [-]AGROVOC Keywords
Bibliographic information
This bibliographic record has been provided by Mediterranean Agronomic Institute of Chania