Inhibition of tea extracts on glucose uptaking by polarized intestinal Caco-2 cells | 茶叶提取物对小肠Caco-2细胞糖吸收的抑制作用
2013
Ni Dejiang, Huazhong Agricultural University, Wuhan (China), College of Horticulture and Forestry Sciences/Key Laboratory of Horticultural Plant Biology, Ministry of Education | Chen Yuqiong, Huazhong Agricultural University, Wuhan (China), College of Horticulture and Forestry Sciences/Key Laboratory of Horticultural Plant Biology, Ministry of Education | Yu Zhi, Huazhong Agricultural University, Wuhan (China), College of Horticulture and Forestry Sciences/Key Laboratory of Horticultural Plant Biology, Ministry of Education
Chinese. 利用水提法制备绿茶、乌龙茶、红茶、青砖茶和普洱茶提取物，研究5种提取物对体外小肠Caco-2细胞吸收葡萄糖的抑制效果。结果表明：在相同质量浓度（O．5mg／mL）条件下，5种茶叶提取物均能抑制Caco-2细胞吸收葡萄糖的活性，抑制能力大小依次为绿茶〉乌龙茶〉红茶〉青砖茶〉普洱茶；与对照相比，绿茶、乌龙茶、红茶和青砖茶提取物极显著抑制葡萄糖的吸收，但普洱茶提取物的抑制效果并未达到显著水平（P〉O．05）。茶叶提取物抑制小肠Caco-Z细胞吸收葡萄糖的能力可能与加工过程中儿茶素的转化有关。
Show more [+] Less [-]English. The green tea extract （GT）,oolong tea extract （OT） ,black tea extract （BT）, Qingzhuan tea extract （QT） and Pu-erh tea extract （PT） were prepared by using water and the effect of them on in- testinal glucose uptaking was investigated using polarized Caco-2 intestinal cells. The extracts （0. 5 mg/mL） inhibited glucose uptaking into the intestinal Caco-2 cells under sodium-dependent conditions in the order： GT〉OT〉BT〉QT〉PT. Compared with control, GT, OT, BT and QT inhibited significantly glucose-uptaking （P〈0.01）, except for PT（P〉0.05）. Catechin may be the predominant inhibitor in tea and its conversion during manufacturing could affect the glucose-uptake inhibitory activity.
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