Inhibitory Effect of Elastase and Tyrosinase of Ginsenoside F1 Isolated from Panax ginseng Leaves
2013
Hong, S.C., International Ginseng and Herb Research Institute, Geumsan, Republic of Korea | Yoo, N.H., International Ginseng and Herb Research Institute, Geumsan, Republic of Korea | Yoo, J.H., International Ginseng and Herb Research Institute, Geumsan, Republic of Korea | Lee, K.H., International Ginseng and Herb Research Institute, Geumsan, Republic of Korea | Kim, B.R., International Ginseng and Herb Research Institute, Geumsan, Republic of Korea | Lee, H.J., International Ginseng and Herb Research Institute, Geumsan, Republic of Korea | Kim, J.M., International Ginseng and Herb Research Institute, Geumsan, Republic of Korea | Seong, N.S., International Ginseng and Herb Research Institute, Geumsan, Republic of Korea | Pyo, M.K., International Ginseng and Herb Research Institute, Geumsan, Republic of Korea
This study was carried to establish a simple isolation and purification method of ginsenoside F1 from leaves of Panax ginseng and was to evaluate the inhibitory effect of purified ginsenoside F1 on the activities of elastase and tyrosinase. The content of ginsenoside F1 was 90-fold higher in leaves than in root of ginseng. Ginsenoside F1 was isolated from EtOAc fraction between EtOAc and alkalized water of 80% EtOH extract after remove of hydrophobic components. The 50% inhibitory concentration (IC50) of ginsenoside F1 on elastase activity and tyrosinase activity was 1.07 mM and 1.81 mM, respectively. Especially, inhibitory effect of ginsenoside F1 on tyrosinase activity was higher than that of arbutin (IC50; 2.20 mM). These results indicate that ginsenoside F1 have a potential for industrial cosmetic materials.
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