Pinoresinol diglucoside is screened as a putative ¥�-glucosidase inhibiting compound in Actinidia arguta leaves
2014
Kwon, D., Chung-Ang University, Anseong, Republic of Korea | Kim, G.D., Chung-Ang University, Anseong, Republic of Korea | Kang, W., Chung-Ang University, Anseong, Republic of Korea | Park, J.E., Chung-Ang University, Anseong, Republic of Korea | Kim, S.H., Chung-Ang University, Anseong, Republic of Korea | Choe, E., Inje University, Gimhae, Republic of Korea | Kim, J.I., Inha University, Incheon, Republic of Korea | Auh, J.H., Chung-Ang University, Anseong, Republic of Korea
Actinidia arguta leaves are consumed as a popular food material in Korea and have been reported to exert beneficial effects on humans due to its constituent polyphenolic compounds. In this study, the ¥�-glucosidase inhibitory compounds in A. arguta were screened and identified through ¥�-glucosidase-guided fractionation and metabolomic analysis. The 50% ethanol extracts of A. arguta showed strong inhibitory effect (32.6%), which was comparable to acarbose as a positive control (30.0%). Through multiple steps of fractionation, pinoresinol diglucoside and fertaric acid were identified as the major potent compounds in A. arguta inhibiting ¥�-glucosidase activity by liquid chromatography mass spectrometry analysis and metabolomic comparison. Particularly, because pinoresinol and its glycosides have been demonstrated as ¥�-glucosidase inhibitory agents, pinoresinol diglucoside was proposed to be a putative key compound for ¥�-glucosidase inhibition in A. arguta. This is the first study demonstrating the anti-diabetic effect of a pinoresinol-containing fraction of A. arguta and would be useful for its application as a natural ¥�-glucosidase inhibitor.
Show more [+] Less [-]AGROVOC Keywords
Bibliographic information
This bibliographic record has been provided by Korea Agricultural Science Digital Library